Laboratory of  Human Molecular Genetics and Genomic Disorders
  The University of Western Ontario
 


This web interface provides a tool to predict the effects of sequence changes that alter mRNA splicing in human diseases. We designed the system to evaluate changes in splice site strength based on information theory-based models of donor and acceptor splice sites.

The resource has been updated and improved by its previous interation. It has been updated with the lastest genomic coordinates (HG19), the newest mRNA tables (UCSC), known SNPs (dbSNP135), and updated donor and acceptor weight matrices. In this iteration, we introduce a method to predict potential isoform structures and their relative abundance.

Watch a tutorial video describing how to use the web server and understand your results. What is this resource?

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February 2nd, 2015 - Notice to ASSEDA Users: The updated version of ASSEDA is now available. All trial users can register at MutationForecaster.com (an expanded web service for the examination of DNA variants), and obtain subscriptions, which will include access to ASSEDA as well as other mutation analysis software.

    

Authors:

Peter Rogan, Ph.D. progan@uwo.ca

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