Laboratory of  Human Molecular Genetics and Genomic Disorders
  The University of Western Ontario

This web interface provides a tool to predict the effects of sequence changes that alter mRNA splicing in human diseases. We designed the system to evaluate changes in splice site strength based on information theory-based models of donor and acceptor splice sites.

The resource has been updated and improved by its previous interation. It has been updated with the lastest genomic coordinates (HG19), the newest mRNA tables (UCSC), known SNPs (dbSNP135), and updated donor and acceptor weight matrices. In this iteration, we introduce a method to predict potential isoform structures and their relative abundance.

Watch a tutorial video describing how to use the web server and understand your results. What is this resource?

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May 14th, 2015 - Update to ASSEDA Logic: There has been recent changes to the Exon Definition formulation in regards to the impact of negative values. This update will not affect individual Ri values, but may affect previous computations of Ri,total involving sites which were abolished. The Logic and Formulation of Exon Definition for Splice and Splicing Regulatory Factors is described in detail here.

March 12th, 2015 - Notice to ASSEDA Users: The updated version of ASSEDA is now available. All trial users can register at (an expanded web service for the examination of DNA variants), and obtain subscriptions, which will include access to ASSEDA as well as other mutation analysis software. Registration for MutationForecaster does not provide access to the original ASSEDA application. Only legacy users with ASSEDA subscriptions can access

March 19th, 2015 - Open Letter For Trial Users.



Peter Rogan, Ph.D.

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